Here’s the full description and reference fields for Enclo (Enclomiphene Citrate) — already saved in the spreadsheet at row 9.
Enclo — Reference Specifications
- CAS Number: 15690-57-0 (enclomiphene base) / 7599-79-3 (citrate salt form commonly supplied)
- Molecular Formula: C₂₆H₂₈ClNO (base) / C₃₂H₃₆ClNO₈ (citrate salt)
- Molecular Weight (g/mol): 405.96 (base) / 599.08 (citrate salt)
- Endotoxin (EU/μg): N/A (small molecule — endotoxin spec applies to peptides/biologics)
The spreadsheet currently stores the base form (CAS 15690-57-0, MW 405.96, formula C₂₆H₂₈ClNO). If you supply the citrate salt instead, let me know and I’ll switch it.
Short Description
Enclomiphene research (Enclo) is a research-grade reference compound supplied for in-vitro laboratory study. Enclomiphene research is the trans-stereoisomer of clomiphene and a selective estrogen receptor modulator (SERM), and is widely referenced in HPG-axis, gonadotropin, and endocrine signaling research models. For research use only — not for human or veterinary consumption.
Description
Enclomiphene — Research Reference Material
Enclomiphene is a research-grade compound supplied for in-vitro laboratory investigation. Mechanistically, Enclomiphene is the trans-stereoisomer of clomiphene and acts as a selective estrogen receptor modulator (SERM) with antagonist activity at hypothalamic estrogen receptors, which has made it a frequently studied reference in HPG-axis (hypothalamic-pituitary-gonadal) research, gonadotropin signaling, and endocrine pathway investigations.
This product is also referenced in the literature under the following terms: enclomiphene citrate, trans-clomiphene, SERM research compound, EnCyzix research reference.
Mechanism of Action (Research Context)
Published peer-reviewed research describes Enclomiphene as a non-steroidal SERM that competitively binds estrogen receptors in the hypothalamus, blocking the negative-feedback signal that estrogen normally exerts on gonadotropin-releasing hormone (GnRH) secretion. This results in upregulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in research models. Investigators commonly use this compound in laboratory studies exploring estrogen-receptor binding, gonadotropin release, and endocrine feedback pathways. Researchers should consult primary literature for current mechanistic understanding.
Product Specifications
- CAS Number: 15690-57-0
- Molecular Formula: C₂₆H₂₈ClNO
- Molecular Weight: 405.96 g/mol
- Form: Capsule (research preparation)
- Endotoxin: N/A (small-molecule compound)
- Purity: Refer to lot-specific Certificate of Analysis
Research Applications
Enclomiphene is referenced in laboratory research focused on selective estrogen receptor modulation, HPG-axis signaling, and gonadotropin regulation. Typical study designs include in-vitro estrogen-receptor binding assays, cell-based reporter assays for ER-α and ER-β activity, gene-expression profiling of LH/FSH-related transcripts, and analytical method development. This product is supplied as a reference standard only and is not formulated, labeled, or packaged for any in-vivo or therapeutic application.
Storage & Handling
Store at room temperature in a dry environment, protected from light. For long-term stability, store sealed at 2–8°C. Always handle in accordance with standard laboratory safety practices. Refer to the lot-specific Certificate of Analysis for stability data and recommended handling.
Quality & Documentation
Each lot is supplied with a Certificate of Analysis (COA) referencing identity, purity, and applicable analytical results (HPLC purity, residual solvents, mass-spectrometry confirmation). The COA is the authoritative source for lot-specific data and supersedes any general product description.
Frequently Asked Questions
What is Enclomiphene? Enclomiphene is the trans-stereoisomer of clomiphene, a selective estrogen receptor modulator (SERM) supplied as a research reference compound for in-vitro laboratory investigation in endocrine and HPG-axis research.
How does Enclomiphene differ from clomiphene? Clomiphene is a mixture of two stereoisomers — enclomiphene (trans) and zuclomiphene (cis). Enclomiphene is the more potent ER-antagonist isomer; zuclomiphene is a weak agonist. Researchers use the isolated trans-isomer when studying receptor antagonism specifically.
Is endotoxin testing applicable? No — endotoxin specifications apply to peptides and biologics. Enclomiphene is a chemically synthesized small molecule; the relevant purity specs are HPLC purity and residual solvents, documented on the COA.
Is this product intended for human use? No. This is a research reference material only and is not formulated, labeled, or packaged for human or veterinary use, diagnostic use, food, cosmetic, or therapeutic application.
What documentation is included? A lot-specific Certificate of Analysis (COA) covering identity, purity, and analytical results.
Research Use Only. This product is intended exclusively for in-vitro laboratory and research applications. Not for human or veterinary consumption, diagnostic use, food, cosmetic, or therapeutic purposes. Handling should be performed only by qualified researchers in an appropriate laboratory setting.
