This product is also referenced in the literature under the following terms: ERR pan-agonist, estrogen-related receptor agonist, exercise mimetic research compound, SLU-PP-332 research reference.
Mechanism of Action (Research Context)
Published peer-reviewed research describes SLU-PP-332 as a synthetic small-molecule activator of all three estrogen-related receptor isoforms (ERRα/β/γ), nuclear receptors that regulate transcriptional programs governing mitochondrial biogenesis, oxidative phosphorylation, and fatty-acid oxidation. ERRs share structural homology with classical estrogen receptors but are constitutively active orphan receptors with distinct transcriptional targets. Investigators commonly use this compound in laboratory studies exploring PGC-1α/ERR signaling, mitochondrial gene expression (NRF1, TFAM), oxidative-capacity assays in skeletal-muscle cell models, and metabolic-flux analysis. Researchers should consult primary literature for current mechanistic understanding.
Product Specifications
- CAS Number: 2417489-91-7
- Molecular Formula: C₁₈H₁₇ClN₄O₃S
- Molecular Weight: 404.87 g/mol
- Form: Capsule (1 mg per capsule, research preparation)
- Endotoxin: N/A (small-molecule compound)
- Purity: Refer to lot-specific Certificate of Analysis
Research Applications
SLU-PP-332 is referenced in laboratory research focused on estrogen-related receptor activation, mitochondrial biogenesis, and oxidative-metabolism pathway studies. Typical study designs include in-vitro receptor-binding and reporter assays for ERRα/β/γ activity, gene-expression profiling of PGC-1α/ERR target genes, mitochondrial respiration assays (Seahorse XF) in C2C12 myotubes and other cell models, and analytical method development. This product is supplied as a reference standard only and is not formulated, labeled, or packaged for any in-vivo or therapeutic application.
Storage & Handling
Store at room temperature in a dry environment, protected from light. For long-term stability, store sealed at 2–8°C. Always handle in accordance with standard laboratory safety practices. Refer to the lot-specific Certificate of Analysis for stability data and recommended handling.
Quality & Documentation
Each lot is supplied with a Certificate of Analysis (COA) referencing identity, purity, and applicable analytical results (HPLC purity, residual solvents, mass-spectrometry confirmation). The COA is the authoritative source for lot-specific data and supersedes any general product description.
Frequently Asked Questions
What is SLU-PP-332? SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptor family (ERRα, ERRβ, ERRγ), supplied as a research reference compound for in-vitro laboratory investigation in mitochondrial-metabolism and exercise-mimetic research.
Why is SLU-PP-332 called an “exercise mimetic” in the literature? Published research describes SLU-PP-332 as activating ERR-driven transcriptional programs that overlap with adaptive responses observed after endurance exercise — including upregulation of mitochondrial biogenesis genes and increased oxidative capacity in muscle-cell models. Researchers use this label as shorthand for the gene-expression overlap, not a clinical claim.
How does SLU-PP-332 differ from classical ERR ligands? Most early ERR research relied on inverse agonists or isoform-selective tool compounds. SLU-PP-332 is notable in the literature as a pan-agonist active at all three ERR isoforms, making it a useful reference standard for studying receptor-class-level effects rather than isoform-specific signaling.
Is endotoxin testing applicable? No — endotoxin specifications apply to peptides and biologics. SLU-PP-332 is a chemically synthesized small molecule; the relevant purity specs are HPLC purity and residual solvents, documented on the COA.
Is this product intended for human use? No. This is a research reference material only and is not formulated, labeled, or packaged for human or veterinary use, diagnostic use, food, cosmetic, or therapeutic application.
What documentation is included? A lot-specific Certificate of Analysis (COA) covering identity, purity, and analytical results.
Research Use Only. This product is intended exclusively for in-vitro laboratory and research applications. Not for human or veterinary consumption, diagnostic use, food, cosmetic, or therapeutic purposes. Handling should be performed only by qualified researchers in an appropriate laboratory setting.
